PUBLICATIONS
Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults: NIMHD Social Epigenomics Program
(Maunakea AK, Phankitnirundorn K, Peres R, Dye C, Juarez R, Walsh C, Slavens C, Park SL, Wilkens LR, Le Marchand L).
Avirulent UG10 Entamoeba histolytica mutant derived from HM-1:IMSS strain shows limited genome variability and aberrant 5-methyl cytosine genomic distribution
(Vargas-Maya NI, Maunakea AK, Ramírez-Montiel FB, Sultana R, Peres R, Cervantes QXM, Nieto ALM, Rangel-Serrano Á, Martínez-Álvarez JA, Páramo-Pérez I, Anaya-Velázquez F, Padilla-Vaca F, Franco B).
Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2. Vaccines
(Umeda L, Torres A, Kunihiro BP, Rubas NC, Wells RK, Phankitnirundorn K, Peres R, Juarez R, Maunakea AK).
Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder
(Allan NP, Yamamoto BY, Kunihiro BP, Nunokawa CKL, Rubas NC, Wells RK, Umeda L, Phankitnirundorn K, Torres A, Peres R).
Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts
(Huang BZ, Binder AM, Quon B, Patel YM, Lum-Jones A, Tiirikainen M, Murphy SE, Loo L, Maunakea AK, Haiman CA, Wilkens LR, Koh WP, Cai Q, Aldrich MC, Siegmund KD, Hecht SS, Yuan JM, Blot WJ, Stram DO, Le Marchand L, Park SL).
HMGB1 mediates microbiome-immune axis dysregulation underlying reduced neutralization capacity in obesity-related post-acute sequelae of SARS-CoV-2.
(Rubas NC, Peres R, Kunihiro BP, Allan NP, Phankitnirundorn K, Wells RK, McCracken T, Lee RH, Umeda L, Conching A, Juarez R, Maunakea AK).
Food Sovereignty as a Path to Health Equity for Indigenous Communities: Introduction to the Focus Issue
(Jernigan VBB, Demientieff LX, Maunakea AK).
The Mauli Ola Study: A Unique Academic-Community Partnership With MA’O Organic Farms to Understand and Address Health Inequities Among Native Hawaiians and Other Pacific Islanders in Hawai’i
(Maunakea AK, Juarez R, Maunakea-Forth JK).
Sequencing the SARS-CoV-2 Genome from Stool Samples of Post-acute Cases Implicates a Novel Mutation Associated with Reduced Antibody Neutralization
(Panova N, Allan NP, Rubas NC, Lee RH, Kunihiro BP, Umeda L, Peres R, Juarez R, Maunakea AK).
Examining the immunoepigenetic-gut microbiome axis in the context of self-esteem among Native Hawaiians and other Pacific Islanders
(Becerra CY, Wells RK, Kunihiro BP, Lee RH, Umeda L, Allan NP, Rubas NC, McCracken TA, Nunokawa CKL, Lee MH, Pidlaoan FGS, Phankitnirondorn K, Dye CK, Yamamoto BY, Peres R, Juarez R, Maunakea AK).
Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study
(Takahashi E, Allan N, Peres R, Ortug A, van der Kouwe AJW, Valli B, Ethier E, Levman J, Baumer N, Tsujimura K, Vargas-Maya NI, McCracken TA, Lee R, Maunakea AK).
Gut microbial indicators of metabolic health underlie age-related differences in obesity and diabetes risk among Native Hawaiians and Pacific Islanders
(Wells RK, Kunihiro BP, Phankitnirundorn K, Peres R, McCracken TA, Umeda L, Lee RH, Kim DY, Juarez R, Maunakea AK).
Frontiers in Cellular and Infection Microbiology, December 2022
Vaccine-Associated Shifts in SARS-CoV-2 Infectivity Among the Native Hawaiian and Other Pacific Islander Population in Hawaii
(Juarez R, Phankitnirundorn K, Ramirez A, Peres R, Maunakea AK, Okihiro M).
Editorial: The biological impact of adversity on cardiovascular disease risk and obesity
(Baumer Y, Farmer N, Maunakea AK, Needham BL, Powell-Wiley TM).
Dynamics of Trust and Consumption of COVID-19 Information Implicate a Mechanism for COVID-19 Vaccine and Booster Uptake
(Juarez R, Kang Z, Okihiro M, Garcia BK, Phankitnirundorn K, Maunakea AK).
Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes
(Dye CK, Corley MJ, Ing C, Lum-Jones A, Li D, Mau MKLM, Maunakea AK).
Opposing Role of Trust as a Modifier of COVID-19 Vaccine Uptake in an Indigenous Population
(Juarez R, Phankitnirundorn K, Okihiro M, Maunakea AK).
Awakening: The Unveiling of Historically Unaddressed Social Inequities During the COVID-19 Pandemic in the United States
(Andrasik MP, Maunakea AK, Oseso L, Rodriguez-Diaz CE, Wallace S, Walters K, Yukawa M).
The Effects of COVID-19 Vaccine Mandates in Hawaii
(Juarez R, Siegal N, Maunakea AK).
Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder
(Shiohama T, Ortug A, Warren JLA, Valli B, Levman J, Faja SK, Tsujimura K, Maunakea AK, Takahashi E).
Adherence to Mediterranean diet impacts gastrointestinal microbial diversity throughout pregnancy
(Miller CB, Benny P, Riel J, Boushey C, Perez R, Khadka V, Qin Y, Maunakea AK, Lee MJ).
Medical School Hotline: Immunoepigenetic-Microbiome Axis: Implications for Health Disparities Research in Native Hawaiians and Pacific Islanders
(Rubas NC, Maunakea AK).
Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase
(Watanabe LM, Hashimoto AC, Torres DJ, Alfulaij N, Peres R, Sultana R, Maunakea AK, Berry MJ, Seale LA).
Supporting Native Hawaiian Health With Community‐Based Social and Biomedical Research
(Kunihiro B, Wells R, McCracken T, Kim DY, Peres R, Sultana R, Maunakea AK).
E hō mai ka ʻike kūpuna no ke ola: links between traditional Native Hawaiian concepts of health and epigenetics
(Leite-Ah Yo K, Avilez K, Hemscheidt T, Ko’omoa Lange D, Maunakea AK).
Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity
(Go RCP, Corley MJ, Ross GW, Petrovitch H, Masaki KH, Maunakea AK, He Q, Tiirikainen MI).
Epigenetic Delay in the Neurodevelopmental Trajectory of DNA Methylation States in Autism Spectrum Disorders
(Corley MJ, Vargas-Maya N, Pang APS, Lum-Jones A, Li D, Khadka V, Sultana R, Blanchard DC, Maunakea AK).
Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults
(Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK).
Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder
(Balaan C, Corley MJ, Eulalio T, Leite-Ahyo K, Pang APS, Fang R, Khadka VS, Maunakea AK, Ward MA).
Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations
(Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L).
A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder
(Lee RWY, Corley MJ, Pang A, Arakaki G, Abbott L, Nishimoto M, Miyamoto R, Lee E, Yamamoto S, Maunakea AK, Lum-Jones A, Wong M).
Linking traditional native Hawaiian concepts of health with epigenetic research: implications toward developing future indigenous health scientists
(Koomoa D, Maunakea AK).
Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment
(Corley MJ, Dye C, D’Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK).
High-throughput sequencing offers new insights into 5-hydroxymethylcytosine
(Pang AP, Sugai C, Maunakea AK).
A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure
(Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S).
Community-Based Participatory Research Integrates Behavioral and Biological Research to Achieve Health Equity for Native Hawaiians
(Townsend CK, Dillard A, Hosoda KK, Maskarinec GG, Maunakea AK, Yoshimura SR, Hughes C, Palakiko DM, Kehauoha BP, Kaholokula JK).
International Journal of Environmental Research and Public Health, December 2015
Semiconductor-based sequencing of genome-wide DNA methylation states
(Corley MJ, Zhang W, Zheng X, Lum-Jones A, Maunakea AK).
Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
(Kraushaar DC, Jin W, Maunakea A, Abraham B, Ha M, Zhao K).
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
(Maunakea AK, Chepelev I, Cui K, Zhao K).
Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle
(Fu H, Maunakea AK, Martin MM, Huang L, Zhang Y, Ryan M, Kim R, Lin CM, Zhao K, Aladjem MI).
Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences
(Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K).
Proceedings of the National Academy of Sciences of USA, April 2011
Epigenome mapping in normal and disease States
(Maunakea AK, Chepelev I, Zhao K).
Conserved role of intragenic DNA methylation in regulating alternative promoters
(Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D’Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF).
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
(Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG).
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells
(Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN).
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3
(Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF).
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8
(Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF).
Permissive Apoptosis-Resistance (PAR): A Two-step Model for Development of Resistance to Anticancer Drugs
(Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A).
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping
(Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y, Weinstein JN).
The bioinformatics of microarray gene expression profiling
(Weinstein JN, Scherf U, Lee JK, Nishizuka S, Gwadry F, Bussey AK, Kim S, Smith LH, Tanabe L, Richman S, Alexander J, Kouros-Mehr H, Maunakea AK, Reinhold WC).
Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni)
(Wang M, Kikuzaki H, Csiszar K, Boyd CD, Maunakea AK, Fong SF, Ghai G, Rosen RT, Nakatani N, Ho CT).
Polynesian ethnobotanicals: a critical role in new drug discovery
(Boyd C, Maunakea AK, Mordan L, Csiszar K).